Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole‐mount radical prostatectomy tissue

Background Expression profiles of erythroblast transformation‐specific (ETS)‐related gene fusions and serine protease inhibitor Kazal‐type 1 (SPINK1) in early onset prostate cancer have not been thoroughly explored. Methods We retrieved 151 radical prostatectomy specimens from young men with prostate cancer (20%) and with anterior located tumors. ETV1 and ETV4 demonstrated rare overexpression in these tumors, particularly in the higher‐grade tumors. Conclusion This study expands the knowledge of the clonal evolution of multifocal cancer in young patients and support differences in relation to racial background and genetics of prostate cancer.