Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins

Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins

A catalytic deaminative alkylation of unactivated olefins is described. The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both α-olefins and internal olefins, thus unlocking a new catalytic platfor...

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Veröffentlicht in:Journal of the American Chemical Society 2019-10, Vol.141 (41), p.16197-16201
Hauptverfasser: Sun, Shang-Zheng, Romano, Ciro, Martin, Ruben
Format: Artikel
Sprache:eng
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Zusammenfassung:A catalytic deaminative alkylation of unactivated olefins is described. The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both α-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp 3–sp 3 linkages, even in the context of late-stage functionalization.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.9b07489