Effect of vitamin D3 supplementation on insulin resistance and β-cell function in prediabetes: a double-blind, randomized, placebo-controlled trial

Observational studies have suggested an inverse association between low serum 25-hydroxyvitamin D [25(OH)D] concentrations and development of type 2 diabetes. High-quality trials are required to test the hypothesis that vitamin D is a direct contributor to type 2 diabetes pathogenesis. The purpose o...

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Veröffentlicht in:	The American journal of clinical nutrition 2019-11, Vol.110 (5), p.1138-1147
Hauptverfasser:	Wallace, Helen J, Holmes, Lauren, Ennis, Cieran N, Cardwell, Christopher R, Woodside, Jayne V, Young, Ian S, Bell, Patrick M, Hunter, Steven J, McKinley, Michelle C
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Adult Aged Beta cells Calciferol Cholecalciferol - administration & dosage Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dietary Supplements Double-Blind Method Double-blind studies euglycemic–hyperinsulinemic clamp Female Glucose Glucose tolerance Humans Insulin Insulin Resistance Insulin-Secreting Cells - physiology Male Middle Aged Pathogenesis prediabetes Prediabetic State - physiopathology Randomization Vitamin D Vitamin D3 β-cell function
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Beschreibung
Zusammenfassung:	Observational studies have suggested an inverse association between low serum 25-hydroxyvitamin D [25(OH)D] concentrations and development of type 2 diabetes. High-quality trials are required to test the hypothesis that vitamin D is a direct contributor to type 2 diabetes pathogenesis. The purpose of this double-blind randomized placebo-controlled trial was to investigate the effect of vitamin D3 supplementation on insulin resistance (IR) and β-cell function in people with prediabetes and suboptimal vitamin D status (
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/nqz171