Is accelerated, high-dose theta burst stimulation a panacea for treatment-resistant depression?

A recent study by Williams et al. (Williams NR, Sudheimer KD, Bentzley BS, Pannu J, Stimpson KH, Duvio D, Cherian K, Hawkins J, Scherrer KH, Vyssoki B, DeSouza D, Raj KS, Keller J, Schatzberg AF. 141: e18, 2018) used accelerated, high-dose intermittent theta burst stimulation (iTBS) to treat highly...

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Veröffentlicht in:	Journal of neurophysiology 2020-01, Vol.123 (1), p.1-3
1. Verfasser:	Caulfield, Kevin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Depressive Disorder, Treatment-Resistant - drug therapy Humans Outcome Assessment, Health Care Transcranial Magnetic Stimulation - methods Transcranial Magnetic Stimulation - standards
Online-Zugang:	Volltext
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Zusammenfassung:	A recent study by Williams et al. (Williams NR, Sudheimer KD, Bentzley BS, Pannu J, Stimpson KH, Duvio D, Cherian K, Hawkins J, Scherrer KH, Vyssoki B, DeSouza D, Raj KS, Keller J, Schatzberg AF. 141: e18, 2018) used accelerated, high-dose intermittent theta burst stimulation (iTBS) to treat highly treatment-resistant depression patients. Remarkably, most patients remitted, but the durability of therapeutic response was weak and all patients relapsed within 2 wk posttreatment. This mini-review examines the "fast on, fast off" effects of accelerated, high-dose iTBS for depression and suggests a new treatment that would combine the strengths of multiple extant iTBS protocols.
ISSN:	0022-3077 1522-1598
DOI:	10.1152/jn.00537.2019