Baicalin improves the in vitro developmental capacity of pig embryos by inhibiting apoptosis, regulating mitochondrial activity and activating sonic hedgehog signaling

Baicalin improves the in vitro developmental capacity of pig embryos by inhibiting apoptosis, regulating mitochondrial activity and activating sonic hedgehog signaling

Baicalin, a traditional Chinese medicinal monomer whose chemical structure is known, can be used to treat female infertility. However, the effect of baicalin on embryonic development is unknown. This study investigated the effects of baicalin on in vitro development of parthenogenetically activated...

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Veröffentlicht in:Molecular human reproduction 2019-09, Vol.25 (9), p.538-549
Hauptverfasser: Guo, Qing, Xuan, Mei-Fu, Luo, Zhao-Bo, Wang, Jun-Xia, Han, Sheng-Zhong, Ri, Myong-Hak, Choe, Yong-Gyu, Hwang, Kyung-Min, Yin, Xi-Jun, Kang, Jin-Dan
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Sprache:eng
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Zusammenfassung:Baicalin, a traditional Chinese medicinal monomer whose chemical structure is known, can be used to treat female infertility. However, the effect of baicalin on embryonic development is unknown. This study investigated the effects of baicalin on in vitro development of parthenogenetically activated (PA) and in vitro fertilized (IVF) pig embryos and the underlying mechanisms involved. Treatment with 0.1 μg/ml baicalin significantly improved (P 
ISSN:1460-2407
1460-2407
DOI:10.1093/molehr/gaz036