MicroRNAs in tumor samples and urinary extracellular vesicles as a putative diagnostic tool for muscle-invasive bladder cancer

Purpose The identification of biomarkers characterizing the invasive potential of bladder cancer could enhance the clinical management of individual patients and therefore improve prognosis. The aim of this study was to define a miRNA panel in tumor tissues as well as in urinary extracellular vesicl...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2019-11, Vol.145 (11), p.2725-2736
Hauptverfasser:	Baumgart, Sophie, Meschkat, Pascal, Edelmann, Philipp, Heinzelmann, Joana, Pryalukhin, Alexey, Bohle, Rainer, Heinzelbecker, Julia, Stöckle, Michael, Junker, Kerstin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Bladder cancer Cancer Cancer Research Carcinoma Extracellular vesicles Hematology Internal Medicine Invasiveness Medicine Medicine & Public Health MicroRNAs miRNA Oncology Original Article – Cancer Research Paraffin Tumors
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Zusammenfassung:	Purpose The identification of biomarkers characterizing the invasive potential of bladder cancer could enhance the clinical management of individual patients and therefore improve prognosis. The aim of this study was to define a miRNA panel in tumor tissues as well as in urinary extracellular vesicles (EVs) for discriminating muscle-invasive bladder cancer (MIBC) from non-muscle-invasive bladder cancer (NMIBC). Methods miRNA expression was analyzed in 24 formalin-fixed, paraffin-embedded (FFPE) tumor samples by microarray analysis and was further validated by qRT-PCR in 56 FFPE tumor samples as well as in 37 urinary EV samples. Results Microarray analysis revealed 63 miRNAs that were significantly differentially expressed ( P
ISSN:	0171-5216 1432-1335
DOI:	10.1007/s00432-019-03035-6