Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

[Display omitted] Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have ena...

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Veröffentlicht in:Current opinion in chemical biology 2019-10, Vol.52, p.112-124
Hauptverfasser: Saarbach, Jacques, Sabale, Pramod M, Winssinger, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antisense Elements (Genetics)
Biosensing Techniques
Diagnosis
Gene Editing
Humans
Molecular Probes
Nucleic Acids - analysis
Nucleic Acids - chemistry
Peptide Nucleic Acids - chemistry
Therapeutics
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Zusammenfassung:[Display omitted] Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2019.06.006