Fabrication of a Tyrosine-Responsive Liquid Quantum Dots Based Biosensor through Host–Guest Chemistry

Fabrication of a Tyrosine-Responsive Liquid Quantum Dots Based Biosensor through Host–Guest Chemistry

Design and fabrication of smart liquid quantum dots (LQDs) with high biomolecule selectivity and specificity remains a challenge. Herein, a multifunctional calix[4]­arene derivative (PCAD) was rationally designed and applied to fabricate a Tyr-responsive CdSe-LQD system through host–guest chemistry....

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Veröffentlicht in:Analytical chemistry (Washington) 2019-10, Vol.91 (20), p.13285-13289
Hauptverfasser: Lu, Xiaoju, Zhan, Yibei, Ouyang, Qingying, Bai, Suya, Chen, Huan, Yu, Yongliang, Zheng, Yifu, Sun, Yao, Li, Haibing
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Biomolecules
Biosensors
Chemistry
Fabrication
Fluorescence
Organic chemistry
Quantum dots
Selectivity
Supramolecular compounds
Tyrosine
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Beschreibung
Zusammenfassung:Design and fabrication of smart liquid quantum dots (LQDs) with high biomolecule selectivity and specificity remains a challenge. Herein, a multifunctional calix[4]­arene derivative (PCAD) was rationally designed and applied to fabricate a Tyr-responsive CdSe-LQD system through host–guest chemistry. Such a biosensor displays an outstanding fluorescence/macroscopic response for Tyr and reversible fluidic features due to the hydrogen interaction between the PCAD of CdSe-LQDs and Tyr. These excellent results highlighted CdSe-LQDs as a promising platform for biological molecule recognition and separation in the future.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.9b04034