ILC2 the Rescue?

Peebles discusses the study by Monticelli and colleagues that describes the innate lymphoid cell (ILC) subsets in donor lungs before and after reperfusion in allograft transplantation while correlating the ILC subsets with primary graft dysfunction (PGD). ILC2s comprise one subset of the five major groups of ILC, which also include natural killer (NK) cells, lymphoid tissue inducer cells, ILC1s, and ILC3s. These subsets are defined by the transcription factors that regulate their differentiation and the cytokines that they secrete. He is also critical on the findings of the study for complementing previous publications in which the numbers of neutrophils, macrophages, and lymphocytes were enumerated in donor tissue in the setting of PGD or non-PGD.