Do IL-7 R+ innate cells orchestrate autoimmune pathology?

Do IL-7 R+ innate cells orchestrate autoimmune pathology?

Immunopathology in autoimmune diseases is promoted by complex interactions between many types of immune cells, and adequate disease inhibition relies on targeting molecules that orchestrate these interactions. One such molecule, IL-7, has well-known effects on lymphoid cells, but could this cytokine...

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Veröffentlicht in:Nature reviews. Rheumatology 2019-11, Vol.15 (11), p.640-642
Hauptverfasser: Hinrichs, Anneline C., van Roon, Joel A. G.
Format: Artikel
Sprache:eng
Schlagworte:
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Arthritis
Autoimmune diseases
Humans
Interleukin 7
Lymphocytes
Lymphoid cells
Macrophages
Medicine
Medicine & Public Health
News & Views
news-and-views
Rheumatology
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Beschreibung
Zusammenfassung:Immunopathology in autoimmune diseases is promoted by complex interactions between many types of immune cells, and adequate disease inhibition relies on targeting molecules that orchestrate these interactions. One such molecule, IL-7, has well-known effects on lymphoid cells, but could this cytokine also affect innate immune cells to induce immunopathology?
ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-019-0297-4