Tacrolimus: Influence of the Posttransplant Concentration/Dose Ratio on Kidney Graft Function in a Two-Year Follow-Up

Abstract Introduction: Tacrolimus (TAC) metabolism rate has the potential to impact graft function after kidney transplantation (KTx). We aimed to analyze the relationship between the early post-KTx TAC C/D ratio (blood trough concentration normalized by total daily dose) and kidney graft function i...

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Veröffentlicht in:	Kidney & blood pressure research 2019-10, Vol.44 (5), p.1075-1088
Hauptverfasser:	Nowicka, Maja, Górska, Monika, Nowicka, Zuzanna, Edyko, Krzysztof, Edyko, Piotr, Wiślicki, Sebastian, Zawiasa-Bryszewska, Anna, Strzelczyk, Janusz, Matych, Józef, Kurnatowska, Ilona
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Analysis Blood levels Complications and side effects Cytochrome Diabetes Drug metabolism Drug therapy Estimated glomerular filtration rate Female Follow-Up Studies Glomerular filtration rate Glomerular Filtration Rate - physiology Graft rejection Grafting Health aspects Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Induction therapy Kidney transplantation Kidney Transplantation - methods Kidney transplants Laboratories Male Metabolism Middle Aged Mycophenolate sodium Organ transplant recipients Organ transplantation Outcome Patient outcomes Physiological aspects Prognosis Renal transplantation Research Article Retrospective Studies Risk factors Steroids Surgery Tacrolimus Tacrolimus - pharmacology Tacrolimus - therapeutic use Testing Transplants & implants Variables
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Zusammenfassung:	Abstract Introduction: Tacrolimus (TAC) metabolism rate has the potential to impact graft function after kidney transplantation (KTx). We aimed to analyze the relationship between the early post-KTx TAC C/D ratio (blood trough concentration normalized by total daily dose) and kidney graft function in a 2-year follow-up. Methods: We retrospectively analyzed data from 101 post-KTx patients at 3, 6, 12, and 24 months after KTx to identify the C/D ratio cutoff value optimal for dividing patients into fast and slow TAC metabolizers. We investigated the relationship between their TAC metabolism rate and graft function. Results: Patients were divided based on the TAC C/D ratio at 6 months after KTx of 1.47 ng/mL * 1 mg. Fast metabolizers (C/D ratio
ISSN:	1420-4096 1423-0143
DOI:	10.1159/000502290