Cancer stem cells and their unique role in metastatic spread

Cancer stem cells and their unique role in metastatic spread

Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation, but also dormancy and cellular plasticity that allow adaption to new environmental circumstances. These abilities are ideal prerequisites for the successful...

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Veröffentlicht in:Seminars in cancer biology 2020-02, Vol.60, p.148-156
Hauptverfasser: Steinbichler, Teresa Bernadette, Savic, Dragana, Dudás, József, Kvitsaridze, Irma, Skvortsov, Sergej, Riechelmann, Herbert, Skvortsova, Ira-Ida
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Animals
Cell Plasticity
Cell Survival
Disease Progression
Disease Susceptibility
Dormancy
EMT
Epithelial-Mesenchymal Transition
Humans
Invasion
Migration
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - metabolism
Stem cell niche
Tumor Microenvironment
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Zusammenfassung:Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation, but also dormancy and cellular plasticity that allow adaption to new environmental circumstances. These abilities are ideal prerequisites for the successful establishment of metastasis. This review highlights the role of CSCs in every step of the metastatic cascade from cancer cell invasion into blood vessels, survival in the blood stream, attachment and extravasation as well as colonization of the host organ and subsequent establishment of distant macrometastasis.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2019.09.007