Meta-analysis of topical vancomycin powder for microbial profile in spinal surgical site infections

Meta-analysis of topical vancomycin powder for microbial profile in spinal surgical site infections

Objectives To systematically evaluate the impact of topical vancomycin powder for microbial profile in spinal surgical site infections. Methods All available literature regarding the topical use of vancomycin powder to prevent postoperative spinal infections was retrieved from the MEDLINE, EMBASE, a...

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Veröffentlicht in:European spine journal 2019-12, Vol.28 (12), p.2972-2980
Hauptverfasser: Li, Sipeng, Rong, Hongtao, Zhang, Xueqin, Zhang, Zhengshan, Wang, Chao, Tan, Rui, Wang, Yi, Zheng, Ting, Zhu, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Bacterial infections
Drug resistance
Gram-negative bacteria
Gram-positive bacteria
Infections
Medicine
Medicine & Public Health
Meta-analysis
Methicillin
Neurosurgery
Powder
Review Article
Surgical Orthopedics
Surgical site infections
Vancomycin
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Zusammenfassung:Objectives To systematically evaluate the impact of topical vancomycin powder for microbial profile in spinal surgical site infections. Methods All available literature regarding the topical use of vancomycin powder to prevent postoperative spinal infections was retrieved from the MEDLINE, EMBASE, and Cochrane databases starting from the creation date and up until September 30, 2018. Results A total of 21 studies involving 15,548 patients were reviewed. The combined odds ratio showed that topical use of vancomycin powder was effective for reducing the incidence of gram-positive bacterial infections in spinal surgical sites (OR 0.41, P  
ISSN:0940-6719
1432-0932
DOI:10.1007/s00586-019-06143-6