Model Informed Drug Development: Novel Oncology Agents are Lost in Translation

Excitement around and investment in oncology drug development are at unprecedented levels. To maximize the health impact and productivity of this research and development investment, quantitative modeling should impact key decisions in early clinical oncology including Go/No-Go decisions based on ea...

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Veröffentlicht in:	Clinical cancer research 2019-11, Vol.25 (22), p.6564-6566
Hauptverfasser:	Mayawala, Kapil, de Alwis, Dinesh P, Sachs, Jeffrey R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols Drug Development Medical Oncology Therapeutic Index Treatment Outcome
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Excitement around and investment in oncology drug development are at unprecedented levels. To maximize the health impact and productivity of this research and development investment, quantitative modeling should impact key decisions in early clinical oncology including Go/No-Go decisions based on early clinical data, and dose selection for late stage studies. .
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-19-2482