First Report of bla VIM-4 - and mcr-9 -Coharboring Enterobacter Species Isolated from a Pediatric Patient

An isolate harboring and was recovered from a pediatric patient in a U.S. hospital. The and genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The gene is located between two insertion elements, IS and...

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Veröffentlicht in:mSphere 2019-09, Vol.4 (5)
Hauptverfasser: Chavda, Kalyan D, Westblade, Lars F, Satlin, Michael J, Hemmert, Andrew C, Castanheira, Mariana, Jenkins, Stephen G, Chen, Liang, Kreiswirth, Barry N
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Sprache:eng
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Zusammenfassung:An isolate harboring and was recovered from a pediatric patient in a U.S. hospital. The and genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The gene is located between two insertion elements, IS and IS , but lacks the downstream regulatory genes ( and ) found in other isolates that harbor We describe the complete genome assembly and sequence of a clinical isolate harboring both and recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an isolate harboring both and from the United States. The and genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The gene is located between two insertion elements, IS and IS , but lacks the downstream regulatory genes ( and ) found in other isolates that harbor .
ISSN:2379-5042
2379-5042
DOI:10.1128/mSphere.00629-19