Analysis of fistula formation of T4 esophageal cancer patients treated by chemoradiotherapy

Background and aim Fistula is one of the known complications of T4 esophageal cancer (T4-EC). The standard treatment for T4-EC is chemoradiotherapy, but detailed data about fistula resulting from chemoradiotherapy in this condition are limited. In particular, radiographic findings of T4-EC with fist...

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Veröffentlicht in:Esophagus : official journal of the Japan Esophageal Society 2020-01, Vol.17 (1), p.67-73
Hauptverfasser: Taniyama, Tomoko Katsui, Tsuda, Takashi, Miyakawa, Kunihisa, Arai, Hiroyuki, Doi, Ayako, Hirakawa, Mami, Horie, Yoshiki, Mizukami, Takuro, Izawa, Naoki, Ogura, Takashi, Sunakawa, Yu, Nakajima, Takako Eguchi
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Sprache:eng
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Zusammenfassung:Background and aim Fistula is one of the known complications of T4 esophageal cancer (T4-EC). The standard treatment for T4-EC is chemoradiotherapy, but detailed data about fistula resulting from chemoradiotherapy in this condition are limited. In particular, radiographic findings of T4-EC with fistula have not been reported. This study assessed the risk factors of fistula based on clinical information on patients with chemoradiotherapy for T4-EC. Methods We retrospectively reviewed the clinical data of 59 T4-EC patients who had squamous cell carcinoma without any fistula before receiving definitive or palliative chemoradiotherapy. Results A fistula was observed in 18 patients (31%) throughout their clinical course. The overall survival in the fistula group was significantly shorter than that in the non-fistula group (259 vs. 346 days; p  = 0.0341). The axial tumor size on computed tomography (CT) was confirmed as an independent risk factor for esophageal fistula in multivariate analysis of stepwise methods [OR 1.226; 95% CI 1.109–1.411; p  
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-019-00691-y