Effect of altered sagittal-plane knee kinematics on loading during the early stance phase of gait

•The effect of altered knee kinematics on knee loads during gait was evaluated.•Decreased knee flexion excursion caused decreased vertical ground reaction force.•Knee flexion moment was linked to flexion angle rather than flexion excursion.•Greater knee flexion angle during early stance increased knee flexion moment. Individuals with knee osteoarthritis (OA) show various dynamic sagittal-plane changes during the early stance phase of gait. However, the effect of these kinematic alterations on knee load during the early stance remains poorly understood. Research question: The purpose of this study was to examine the effect of altered sagittal- plane knee kinematics on knee load during the early stance. A total of 13 healthy adult men underwent gait analysis trials using four conditions (baseline and three altered conditions). The three altered conditions were defined as follows: 1) Less flexion (LF): a gait that decreased knee flexion excursion (KFE) owing to a reduced peak knee flexion angle compared to baseline. 2) Initial flexion (IF): a gait with decreased KFE owing to an increased knee flexion angle at initial contact, during which the peak knee flexion angle did not differ from baseline. 3) Flexion gait (FG): a gait that increased the knee flexion angle at initial contact but did not reduce KFE compared with the baseline. Data analyzed included peak external knee flexion moment (KFM), KFM impulse (impulse was an integral value from initial contact to peak value), peak vertical ground reaction force (VGRF), and maximum loading rate. Both LF and IF conditions significantly decreased peak VGRF (p