The impact of porcine circovirus associated diseases on live attenuated classical swine fever vaccine in field farm applications

The impact of porcine circovirus associated diseases on live attenuated classical swine fever vaccine in field farm applications

Highlights•A vaccination-challenge animal model was conducted to mimic different statuses of PCVADs. •The impaired efficacy of subunit PCV2 vaccine was demonstrated with a conventional pig model after PCV2 challenge. •The efficacy of live attenuated CSFV vaccine was compromised in PCV2-SI and PCV2-S...

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Veröffentlicht in:Vaccine 2019-10, Vol.37 (43), p.6535-6542
Hauptverfasser: Chen, Jing-Yuan, Wu, Chi-Ming, Liao, Chih-Ming, Chen, Kun-Chao, You, Chia-Chin, Wang, Yu-Wen, Huang, Chienjin, Chien, Maw-Sheng
Format: Artikel
Sprache:eng
Schlagworte:
Age
Allergy and Immunology
Antibodies
Antigens
Attenuation
Classical swine fever live attenuated vaccine
Clinical trials
Concurrent infection
Disease
Disease control
Effectiveness
Epidemics
Farms
Fever
Hog cholera
Hogs
Immune response
Immune system
Immunization
Immunoglobulins
Infections
Laboratories
Levels
Lymph nodes
Porcine circovirus associated diseases
Risk analysis
Risk factors
Subclinical infection
Subunit porcine circovirus type 2 vaccine
Swine
Vaccination-challenge model
Vaccines
Viruses
Weaning
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Beschreibung
Zusammenfassung:Highlights•A vaccination-challenge animal model was conducted to mimic different statuses of PCVADs. •The impaired efficacy of subunit PCV2 vaccine was demonstrated with a conventional pig model after PCV2 challenge. •The efficacy of live attenuated CSFV vaccine was compromised in PCV2-SI and PCV2-SD pigs.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.08.039