Starch microsponges for enhanced retention and efficacy of topical sunscreen

Topical sunscreen products are universally applied by numerous individuals to protect their skin from the detrimental effects of UV radiation. However, lately, studies have revealed the risks associated with percutaneous absorption of UV filters leading to undesirable systemic side effects such as h...

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Veröffentlicht in:	Materials Science & Engineering C 2019-11, Vol.104, p.109882-109882, Article 109882
Hauptverfasser:	Bhuptani, Ronak S., Patravale, Vandana B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Allergies Benzophenone Benzophenone‑3 Biocompatibility Calorimetry Calorimetry, Differential Scanning - methods Cream Desorption Differential scanning calorimetry Drug Delivery Systems - methods Evaporation Fourier transforms Humans Infrared spectroscopy Materials science Menopause Microsponges Morphology Nitrogen Oxybenzone Pore size Porosity Porous Rheological properties Scanning electron microscopy Side effects Skin Skin - drug effects Skin Absorption - drug effects Starch Starch - chemistry Submerging Sun screens Sunscreen Sunscreening Agents - chemistry Sunscreening Agents - pharmacology Texture Ultraviolet filters Ultraviolet radiation X ray powder diffraction X-ray diffraction X-Ray Diffraction - methods
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Zusammenfassung:	Topical sunscreen products are universally applied by numerous individuals to protect their skin from the detrimental effects of UV radiation. However, lately, studies have revealed the risks associated with percutaneous absorption of UV filters leading to undesirable systemic side effects such as hormonal disturbances and allergies. In this study, an innovative sunscreen formulation was developed based on starch microsponges as a key carrier encapsulating an organic sunscreen benzophenone‑3. The developed starch microsponges were characterized by scanning electron microscopy and nitrogen adsorption/desorption analysis. The results showed that starch microsponges possessed a high BET surface area (85.45 m2/g) with spherical porous morphology with pore size
ISSN:	0928-4931 1873-0191
DOI:	10.1016/j.msec.2019.109882