Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors

We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprot...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.574-579
Hauptverfasser:	Mitroshina, E. V., Mishchenko, T. A, Shishkina, T. V., Vedunova, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell Biology Cell viability Cells, Cultured Dextrose Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - metabolism Glucose Hippocampus Internal Medicine Ischemia Ischemia - metabolism Laboratory Medicine Mice Mice, Inbred C57BL Nervous system Nervous System - cytology Nervous System - metabolism Neurons Neuroprotection Neurotrophic factors Pathology Physiological aspects
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Beschreibung
Zusammenfassung:	We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04574-1