Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents

In the field of organic synthesis, the advent of flow chemistry and flow microreactor technology represented a tremendous novelty in the way of thinking and performing chemical reactions, opening the doors to poorly explored or even impossible transformations using batch methods. In this Concept article, we would like to highlight the impact of flow chemistry for exploiting highly reactive organometallic reagents, and how, alongside the well‐known advantages concerning safety, scalability, and productivity, flow chemistry makes possible processes that are impossible to control by using the traditional batch approach. Let it flow: The advent of flow chemistry and microreactor technology represented a tremendous novelty in the way of thinking and performing chemical reactions, opening the doors to poorly explored or impossible transformations. We wish to highlight herein the impact of flow chemistry in the use of highly reactive organometallic reagents in modern synthesis.