Exploring the mechanism of clear cell renal cell carcinoma metastasis and key genes based on multi-tool joint analysis

Exploring the mechanism of clear cell renal cell carcinoma metastasis and key genes based on multi-tool joint analysis

Clear cell renal cell carcinoma (ccRCC) is a highly invasive urological malignant tumor that results in shorter patient survival. At present, the mechanism of ccRCC metastasis is not clear. We explored the possible mechanisms of ccRCC metastasis by analyzing the transcriptome of ccRCC patients from...

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Veröffentlicht in:Gene 2019-12, Vol.720, p.144103-144103, Article 144103
Hauptverfasser: Yang, Haisheng, Li, Wanqiu, Lv, Yingnan, Fan, Qiuyu, Mao, Xingning, Long, Tianzhu, Xie, Lianguang, Dong, Chunting, Yang, Rongqing, Zhang, Haiying
Format: Artikel
Sprache:eng
Schlagworte:
Clear cell renal cell carcinoma
Metastasis
TCGA
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Zusammenfassung:Clear cell renal cell carcinoma (ccRCC) is a highly invasive urological malignant tumor that results in shorter patient survival. At present, the mechanism of ccRCC metastasis is not clear. We explored the possible mechanisms of ccRCC metastasis by analyzing the transcriptome of ccRCC patients from the Cancer Genome Atlas (TCGA) database. Comparing the differences in transcriptome in patients with and without metastasis, we found 323 differential genes (|log2FoldChange| > 1 and P 
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2019.144103