RUNX transcription factors: orchestrators of development

RUNX transcription factors: orchestrators of development

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Development (Cambridge) 2019-09, Vol.146 (17)
Hauptverfasser: Mevel, Renaud, Draper, Julia E, Lie-A-Ling, Michael, Kouskoff, Valerie, Lacaud, Georges
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Core Binding Factor alpha Subunits - genetics
Core Binding Factor alpha Subunits - metabolism
Gene Expression Regulation, Developmental
Genetic Loci
Hematopoiesis - physiology
Homeostasis - physiology
Humans
Mammals - embryology
Mammals - metabolism
Mice
Neoplasms - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
ISSN:0950-1991
1477-9129
DOI:10.1242/dev.148296