Assessment of small sensory fiber function in myotonic dystrophy type 1
Background Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking. Methods Using quantitative sensory testing of the hand and foot, we...
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| Veröffentlicht in: | Muscle & nerve 2019-11, Vol.60 (5), p.575-579 |
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| creator | Boland‐Freitas, Robert Ng, Karl |
| description | Background
Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking.
Methods
Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C‐fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age‐ and sex‐matched controls.
Results
No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P |
| doi_str_mv | 10.1002/mus.26673 |
| format | Article |
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Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking.
Methods
Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C‐fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age‐ and sex‐matched controls.
Results
No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P < .01) and foot (P = 0.02) warm detection thresholds were higher than those of controls. Cool detection thresholds were lower in the foot (P < .001).
Conclusions
Subclinical small sensory fiber dysfunction occurs in DM1 patients without large fiber neuropathy. Further research with other modalities is required to characterize these disturbances as disease modifying therapies are developed.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26673</identifier><identifier>PMID: 31443127</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Case-Control Studies ; Diabetes mellitus ; Diabetic neuropathy ; Dystrophy ; Evaluation ; Feet ; Female ; Foot - innervation ; Hand - innervation ; Humans ; Male ; Marstock method of limits ; Middle Aged ; Myotonic dystrophy ; Myotonic Dystrophy - physiopathology ; Nerve Fibers, Myelinated - physiology ; Nerve Fibers, Unmyelinated - physiology ; Nervous system ; Neural Conduction ; neuropathy ; Pain ; Peripheral nervous system ; quantitative sensory testing ; Sensory neurons ; Sensory testing ; Sensory Thresholds ; small fiber ; thermal thresholds ; Thermosensing - physiology ; Thresholds ; Young Adult</subject><ispartof>Muscle & nerve, 2019-11, Vol.60 (5), p.575-579</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-bc39fbacfc12173875f38d93abecd782036f34ebb3bb7639d95d0c52af97e3173</citedby><cites>FETCH-LOGICAL-c3533-bc39fbacfc12173875f38d93abecd782036f34ebb3bb7639d95d0c52af97e3173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26673$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26673$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31443127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boland‐Freitas, Robert</creatorcontrib><creatorcontrib>Ng, Karl</creatorcontrib><title>Assessment of small sensory fiber function in myotonic dystrophy type 1</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Background
Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking.
Methods
Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C‐fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age‐ and sex‐matched controls.
Results
No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P < .01) and foot (P = 0.02) warm detection thresholds were higher than those of controls. Cool detection thresholds were lower in the foot (P < .001).
Conclusions
Subclinical small sensory fiber dysfunction occurs in DM1 patients without large fiber neuropathy. Further research with other modalities is required to characterize these disturbances as disease modifying therapies are developed.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetic neuropathy</subject><subject>Dystrophy</subject><subject>Evaluation</subject><subject>Feet</subject><subject>Female</subject><subject>Foot - innervation</subject><subject>Hand - innervation</subject><subject>Humans</subject><subject>Male</subject><subject>Marstock method of limits</subject><subject>Middle Aged</subject><subject>Myotonic dystrophy</subject><subject>Myotonic Dystrophy - physiopathology</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nerve Fibers, Unmyelinated - physiology</subject><subject>Nervous system</subject><subject>Neural Conduction</subject><subject>neuropathy</subject><subject>Pain</subject><subject>Peripheral nervous system</subject><subject>quantitative sensory testing</subject><subject>Sensory neurons</subject><subject>Sensory testing</subject><subject>Sensory Thresholds</subject><subject>small fiber</subject><subject>thermal thresholds</subject><subject>Thermosensing - physiology</subject><subject>Thresholds</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAYhoMobk4P_gMS8KKHbvnRNulRhk5h4kEH3kKTJtjRNjNfi_S_t6PTg-Dpuzzf8768CF1SMqeEsEXdwZylqeBHaEpJJqI4yeQxmhIayyjl2fsEnQFsCSFUpuIUTTiNY06ZmKLVHYAFqG3TYu8w1HlVYbAN-NBjV2obsOsa05a-wWWD6963vikNLnpog9999LjtdxbTc3Ti8grsxeHO0Obh_m35GK1fVk_Lu3VkeMJ5pA3PnM6NM5RRwaVIHJdFxnNtTSEkIzx1PLZac63F0LzIkoKYhOUuE5YPHzN0M3p3wX92FlpVl2BsVeWN9R0oxmRCCaVcDuj1H3Tru9AM7RSLU5mmCRvyZuh2pEzwAME6tQtlnYdeUaL266p6r92vO7BXB2Ona1v8kj9zDsBiBL7Kyvb_m9Tz5nVUfgORx4Os</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Boland‐Freitas, Robert</creator><creator>Ng, Karl</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201911</creationdate><title>Assessment of small sensory fiber function in myotonic dystrophy type 1</title><author>Boland‐Freitas, Robert ; Ng, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-bc39fbacfc12173875f38d93abecd782036f34ebb3bb7639d95d0c52af97e3173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetic neuropathy</topic><topic>Dystrophy</topic><topic>Evaluation</topic><topic>Feet</topic><topic>Female</topic><topic>Foot - innervation</topic><topic>Hand - innervation</topic><topic>Humans</topic><topic>Male</topic><topic>Marstock method of limits</topic><topic>Middle Aged</topic><topic>Myotonic dystrophy</topic><topic>Myotonic Dystrophy - physiopathology</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Nerve Fibers, Unmyelinated - physiology</topic><topic>Nervous system</topic><topic>Neural Conduction</topic><topic>neuropathy</topic><topic>Pain</topic><topic>Peripheral nervous system</topic><topic>quantitative sensory testing</topic><topic>Sensory neurons</topic><topic>Sensory testing</topic><topic>Sensory Thresholds</topic><topic>small fiber</topic><topic>thermal thresholds</topic><topic>Thermosensing - physiology</topic><topic>Thresholds</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boland‐Freitas, Robert</creatorcontrib><creatorcontrib>Ng, Karl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boland‐Freitas, Robert</au><au>Ng, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of small sensory fiber function in myotonic dystrophy type 1</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2019-11</date><risdate>2019</risdate><volume>60</volume><issue>5</issue><spage>575</spage><epage>579</epage><pages>575-579</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Background
Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking.
Methods
Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C‐fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age‐ and sex‐matched controls.
Results
No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P < .01) and foot (P = 0.02) warm detection thresholds were higher than those of controls. Cool detection thresholds were lower in the foot (P < .001).
Conclusions
Subclinical small sensory fiber dysfunction occurs in DM1 patients without large fiber neuropathy. Further research with other modalities is required to characterize these disturbances as disease modifying therapies are developed.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31443127</pmid><doi>10.1002/mus.26673</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Case-Control Studies Diabetes mellitus Diabetic neuropathy Dystrophy Evaluation Feet Female Foot - innervation Hand - innervation Humans Male Marstock method of limits Middle Aged Myotonic dystrophy Myotonic Dystrophy - physiopathology Nerve Fibers, Myelinated - physiology Nerve Fibers, Unmyelinated - physiology Nervous system Neural Conduction neuropathy Pain Peripheral nervous system quantitative sensory testing Sensory neurons Sensory testing Sensory Thresholds small fiber thermal thresholds Thermosensing - physiology Thresholds Young Adult |
| title | Assessment of small sensory fiber function in myotonic dystrophy type 1 |
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