Assessment of small sensory fiber function in myotonic dystrophy type 1

Background Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking. Methods Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C‐fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age‐ and sex‐matched controls. Results No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P