Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-09, Vol.55 (76), p.11358-11361
Hauptverfasser: Jiang, Ao, Chen, Guang, Xu, Jie, Liu, Yuxia, Zhao, Guanghui, Liu, Zhenjun, Chen, Tao, Li, Yulin, James, Tony D
Format: Artikel
Sprache:eng
Schlagworte:
Acidification
Fluorescent indicators
Photons
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Zusammenfassung:We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05759e