Resolving mitochondrial haplogroups B2 and B4 with next-generation mitogenome sequencing to distinguish Native American from Asian haplotypes

Highlights•56 haplogroup B mitochondrial genome sequences are presented. •A phylogenetic assessment reinforces the separation of haplogroups B2 and B4b1. •Variants distinguishing Native American B2 and Asian B4 haplotypes are identified. •The use of mitochondrial DNA as an ancestry informative marke...

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Veröffentlicht in:	Forensic science international : genetics 2019-11, Vol.43, p.102143-102143, Article 102143
Hauptverfasser:	Wood, Melody R, Sturk-Andreaggi, Kimberly, Ring, Joseph D, Huber, Nicole, Bodner, Martin, Crawford, Michael H, Parson, Walther, Marshall, Charla
Format:	Artikel
Sprache:	eng
Schlagworte:	Ancestry Asian Continental Ancestry Group - genetics DNA, Mitochondrial - genetics Genome, Mitochondrial Haplogroup B Haplotypes High-Throughput Nucleotide Sequencing Humans Indians, North American - genetics Mitochondrial genome Next-generation sequencing Pathology Phylogenetics Phylogeny Polymerase Chain Reaction Sequence Analysis, DNA
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Zusammenfassung:	Highlights•56 haplogroup B mitochondrial genome sequences are presented. •A phylogenetic assessment reinforces the separation of haplogroups B2 and B4b1. •Variants distinguishing Native American B2 and Asian B4 haplotypes are identified. •The use of mitochondrial DNA as an ancestry informative marker is discussed.
ISSN:	1872-4973 1878-0326
DOI:	10.1016/j.fsigen.2019.102143