Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study
Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using...
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| Veröffentlicht in: | Magnetic resonance imaging 2019-11, Vol.63, p.235-243 |
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| creator | Fujita, Shohei Hagiwara, Akifumi Hori, Masaaki Warntjes, Marcel Kamagata, Koji Fukunaga, Issei Andica, Christina Maekawa, Tomoko Irie, Ryusuke Takemura, Mariko Yoshida Kumamaru, Kanako Kunishima Wada, Akihiko Suzuki, Michimasa Ozaki, Yutaka Abe, Osamu Aoki, Shigeki |
| description | Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look–Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution.
To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.
Scan–rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 ± 3.6 years). Simple linear regression analysis, Bland–Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.
In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively.
3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range. |
| doi_str_mv | 10.1016/j.mri.2019.08.031 |
| format | Article |
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To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.
Scan–rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 ± 3.6 years). Simple linear regression analysis, Bland–Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.
In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively.
3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2019.08.031</identifier><identifier>PMID: 31445118</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Brain - diagnostic imaging ; Brain Mapping ; Female ; Healthy Volunteers ; Humans ; Image Processing, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Linear Models ; Magnetic Resonance Imaging ; Male ; Myelin ; Myelin Sheath - chemistry ; Phantoms, Imaging ; Proton density ; Quantitative magnetic resonance imaging ; Reference Values ; Regression Analysis ; Relaxation time ; Relaxometry ; Reproducibility of Results ; Synthetic magnetic resonance imaging ; Young Adult</subject><ispartof>Magnetic resonance imaging, 2019-11, Vol.63, p.235-243</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-ef6ececcf6af0cbf6d36ea651575957b9189d5367127a471fe4cb0ef63c5bd263</citedby><cites>FETCH-LOGICAL-c396t-ef6ececcf6af0cbf6d36ea651575957b9189d5367127a471fe4cb0ef63c5bd263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0730725X19303650$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31445118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujita, Shohei</creatorcontrib><creatorcontrib>Hagiwara, Akifumi</creatorcontrib><creatorcontrib>Hori, Masaaki</creatorcontrib><creatorcontrib>Warntjes, Marcel</creatorcontrib><creatorcontrib>Kamagata, Koji</creatorcontrib><creatorcontrib>Fukunaga, Issei</creatorcontrib><creatorcontrib>Andica, Christina</creatorcontrib><creatorcontrib>Maekawa, Tomoko</creatorcontrib><creatorcontrib>Irie, Ryusuke</creatorcontrib><creatorcontrib>Takemura, Mariko Yoshida</creatorcontrib><creatorcontrib>Kumamaru, Kanako Kunishima</creatorcontrib><creatorcontrib>Wada, Akihiko</creatorcontrib><creatorcontrib>Suzuki, Michimasa</creatorcontrib><creatorcontrib>Ozaki, Yutaka</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><title>Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look–Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution.
To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.
Scan–rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 ± 3.6 years). Simple linear regression analysis, Bland–Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.
In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively.
3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.</description><subject>Adult</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Myelin</subject><subject>Myelin Sheath - chemistry</subject><subject>Phantoms, Imaging</subject><subject>Proton density</subject><subject>Quantitative magnetic resonance imaging</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Relaxation time</subject><subject>Relaxometry</subject><subject>Reproducibility of Results</subject><subject>Synthetic magnetic resonance imaging</subject><subject>Young Adult</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpabZpf0AvRcde7EqWJdntaUn6EVgIoSn0JmR5HM9iy44kJ-xP6L-ul017zGlgeN4XZh5C3nOWc8bVp30-BswLxuucVTkT_AXZ8EqLTFZ1-ZJsmBYs04X8fUbexLhnjMlCyNfkTPCylJxXG_Lntg8AWYsj-IiTtwPt8a7PAsRpWNK6oRHHZUjWw7REer9YnzDZhA9ARzvP6O_o1NHUA33spwFoEyx6-oipp-Iyu9nutj8_062n1rklWHeg1rc0wAw22QYHTAca09Ie3pJXnR0ivHua5-TXt6-3Fz-y3fX3q4vtLnOiVimDToED5zplO-aaTrVCgVWSSy1rqZuaV3UrhdK80LbUvIPSNWxNCSebtlDinHw89c5hul8gJjNidDAMpwtNUVSCs1rpI8pPqAtTjAE6MwccbTgYzszRgNmb1YA5GjCsMquBNfPhqX5pRmj_J_69fAW-nABYj3xACCY6BO-gxQAumXbCZ-r_AvRFmdc</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Fujita, Shohei</creator><creator>Hagiwara, Akifumi</creator><creator>Hori, Masaaki</creator><creator>Warntjes, Marcel</creator><creator>Kamagata, Koji</creator><creator>Fukunaga, Issei</creator><creator>Andica, Christina</creator><creator>Maekawa, Tomoko</creator><creator>Irie, Ryusuke</creator><creator>Takemura, Mariko Yoshida</creator><creator>Kumamaru, Kanako Kunishima</creator><creator>Wada, Akihiko</creator><creator>Suzuki, Michimasa</creator><creator>Ozaki, Yutaka</creator><creator>Abe, Osamu</creator><creator>Aoki, Shigeki</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201911</creationdate><title>Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study</title><author>Fujita, Shohei ; 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The 3D-quantification using an interleaved Look–Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution.
To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.
Scan–rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 ± 3.6 years). Simple linear regression analysis, Bland–Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.
In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively.
3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>31445118</pmid><doi>10.1016/j.mri.2019.08.031</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Brain - diagnostic imaging Brain Mapping Female Healthy Volunteers Humans Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Linear Models Magnetic Resonance Imaging Male Myelin Myelin Sheath - chemistry Phantoms, Imaging Proton density Quantitative magnetic resonance imaging Reference Values Regression Analysis Relaxation time Relaxometry Reproducibility of Results Synthetic magnetic resonance imaging Young Adult |
| title | Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study |
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