Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation

Brainstem necrosis is a rare, but dreaded complication of radiation therapy; however, data on the incidence of brainstem injury for tumors involving the posterior fossa in photon-treated patient cohorts are still needed. Clinical characteristics and dosimetric parameters were recorded for 107 pediat...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-12, Vol.105 (5), p.1034-1042
Hauptverfasser:	Devine, Christopher A., Liu, Kevin X., Ioakeim-Ioannidou, Myrsini, Susko, Matthew, Poussaint, Tina Y., Huisman, Thierry A.G.M., Aboian, Mariam, Brown, Douglas, Zaslowe-Dude, Cierra, Rao, Avani D., Orlina, Lawrence T., Rawal, Bhupendra, Mueller, Sabine, Marcus, Karen J., Terezakis, Stephanie A., Braunstein, Steve E., Haas-Kogan, Daphne A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Brain Stem - diagnostic imaging Brain Stem - pathology Brain Stem - radiation effects Child Child, Preschool Craniospinal Irradiation - adverse effects Craniospinal Irradiation - statistics & numerical data Ependymoma - radiotherapy Female Humans Incidence Infant Infratentorial Neoplasms - diagnostic imaging Infratentorial Neoplasms - radiotherapy Magnetic Resonance Imaging Male Medulloblastoma - radiotherapy Necrosis - etiology Photons - adverse effects Radiation Injuries - diagnostic imaging Radiation Injuries - epidemiology Radiation Injuries - pathology Radiotherapy Dosage Retrospective Studies Young Adult
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Beschreibung
Zusammenfassung:	Brainstem necrosis is a rare, but dreaded complication of radiation therapy; however, data on the incidence of brainstem injury for tumors involving the posterior fossa in photon-treated patient cohorts are still needed. Clinical characteristics and dosimetric parameters were recorded for 107 pediatric patients who received photon radiation for posterior fossa tumors without brainstem involvement from 2000 to 2016. Patients were excluded if they received a prescription dose
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2019.08.039