Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids ( 1 – 4 ) from Casearia kurzii . The structures of these compounds were established by analysis of their NMR, MS, and electronic circula...

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Veröffentlicht in:	Journal of natural medicines 2019-09, Vol.73 (4), p.826-833
Hauptverfasser:	Shuo, Yuan, Zhang, Chenyue, Yang, Xueyuan, Liu, Feng, Zhang, Qi, Li, Annan, Ma, Jun, Lee, Dongho, Ohizumi, Yasushi, Guo, Yuanqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Biomedical and Life Sciences Biomedicine Casearia Casearia - chemistry Cell Line, Tumor Circular Dichroism Complementary & Alternative Medicine Cytotoxicity Diterpenes Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology Drug Screening Assays, Antitumor HeLa Cells Humans Magnetic Resonance Spectroscopy Medicinal Chemistry Molecular Structure Natural products Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Plants, Medicinal - chemistry Tumor cell lines
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Zusammenfassung:	A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids ( 1 – 4 ) from Casearia kurzii . The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC 50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-019-01324-5