Evaluation of the protective effects of a nanogel-based vaccine against rabbit hepatitis E virus

Evaluation of the protective effects of a nanogel-based vaccine against rabbit hepatitis E virus

Highlights•A nanogel vaccine encapsulating rabbit HEV capsid protein was developed. •The nanogel vaccine induced anti-HEV antibodies, IL-12, and IFN-γ. •The nanogel vaccine completely protected rabbits from HEV infection.

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Bibliographische Detailangaben
Veröffentlicht in:Vaccine 2019-09, Vol.37 (40), p.5972-5978
Hauptverfasser: Park, Byung-Joo, Ahn, Hee-Seop, Han, Sang-Hoon, Go, Hyeon-Jeong, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Paik, Hyun-Jong, Choi, Yang-Kyu, Choi, In-Soo
Format: Artikel
Sprache:eng
Schlagworte:
Alanine
Alanine transaminase
Allergy and Immunology
Animal species
Animal vaccines
Antibodies
Aspartate aminotransferase
Capsid protein
Disease
Feces
Hepatitis
HEV
Immunity
Immunization
Infections
Interferon
Interleukin 12
Laboratory animals
Liver
Nanogel
Pathogenesis
Proteins
Public health
Rabbit
Rabbits
Subunit
Vaccine
Vaccines
Viremia
Viruses
Zoonoses
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Beschreibung
Zusammenfassung:Highlights•A nanogel vaccine encapsulating rabbit HEV capsid protein was developed. •The nanogel vaccine induced anti-HEV antibodies, IL-12, and IFN-γ. •The nanogel vaccine completely protected rabbits from HEV infection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.08.029