The relevance of Fas/Fas ligand axis in the tumor microenvironment of salivary gland adenoid cystic carcinoma

The relevance of Fas/Fas ligand axis in the tumor microenvironment of salivary gland adenoid cystic carcinoma

Highlights•Fas/Fas ligand axis is used by CD8 T cells and NK cells to eliminate tumor cells. •Tumor microenvironment may induce apoptosis of TILs by Fas/Fas ligand axis. •The loss of TILs is one of the main factors responsible for immunotherapy resistance. •Fas/Fas ligand in salivary gland ACC may b...

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Veröffentlicht in:Oral oncology 2019-10, Vol.97, p.135-136
Hauptverfasser: Kuchar, M, Strizova, Z, Votava, M, Plzak, J
Format: Artikel
Sprache:eng
Schlagworte:
Adenoid cystic carcinoma
CD8 T cells
Checkpoint inhibitors
Fas ligand
Granzyme
Hematology, Oncology, and Palliative Medicine
Otolaryngology
PD-L1
Salivary gland carcinoma
Tumor microenvironment
Tumor-infiltrating lymphocytes
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Zusammenfassung:Highlights•Fas/Fas ligand axis is used by CD8 T cells and NK cells to eliminate tumor cells. •Tumor microenvironment may induce apoptosis of TILs by Fas/Fas ligand axis. •The loss of TILs is one of the main factors responsible for immunotherapy resistance. •Fas/Fas ligand in salivary gland ACC may be considered for therapeutic intervention.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2019.08.015