Results of a prospective clinical trial JN‐L‐10 using image‐defined risk factors to inform surgical decisions for children with low‐risk neuroblastoma disease: A report from the Japan Children's Cancer Group Neuroblastoma Committee

Background The present study sought to reduce the incidence of treatment complications of low‐risk neuroblastoma by using image‐defined risk factors (IDRFs) to inform the timing of surgical resection. Procedures Eligible patients included children (

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Veröffentlicht in:	Pediatric blood & cancer 2019-11, Vol.66 (11), p.e27914-n/a
Hauptverfasser:	Iehara, Tomoko, Yoneda, Akihiro, Yokota, Isao, Takahashi, Hideto, Teramukai, Satoshi, Kamijyo, Takehiko, Nakazawa, Atsuko, Takimoto, Tetsuya, Kikuta, Atsushi, Yagyu, Shigeki, Ikeda, Hitoshi, Nakagawara, Akira, Tajiri, Tatsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Ascites Atrophy Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Chemotherapy Chemotherapy-Induced Febrile Neutropenia - etiology Child Child, Preschool Children Clinical Decision-Making Clinical trials Combined Modality Therapy Complications Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Decision making Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - analogs & derivatives Female Ganglioneuroblastoma - diagnostic imaging Ganglioneuroblastoma - drug therapy Ganglioneuroblastoma - surgery Health risks Hematology Humans IDRFs Incidence Infant Infant, Newborn Infants Japan Kaplan-Meier Estimate low‐risk Magnetic Resonance Imaging Male Medical prognosis Medical treatment Neuroblastoma Neuroblastoma - diagnostic imaging Neuroblastoma - drug therapy Neuroblastoma - surgery Neutropenia Oncology Patients Pediatrics Pleural effusion Pleural Effusion - etiology Postoperative Complications - etiology Progression-Free Survival Prospective Studies Risk Factors Surgery Survival Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Toxicity Vascular Diseases - etiology Vincristine Vincristine - administration & dosage Vincristine - adverse effects
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Zusammenfassung:	Background The present study sought to reduce the incidence of treatment complications of low‐risk neuroblastoma by using image‐defined risk factors (IDRFs) to inform the timing of surgical resection. Procedures Eligible patients included children (
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.27914