Seven-Day Salt Loading Impairs Microvascular Endothelium-Dependent Vasodilation without Changes in Blood Pressure, Body Composition and Fluid Status in Healthy Young Humans

Seven-Day Salt Loading Impairs Microvascular Endothelium-Dependent Vasodilation without Changes in Blood Pressure, Body Composition and Fluid Status in Healthy Young Humans

Objectives: We aimed to assess whether a 7-day high-salt (HS) diet affects endothelium-dependent and/or endothelium-independent microvascular function in the absence of changes in arterial blood pressure (BP), and to determine whether such microvascular changes are associated with changes in body co...

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Veröffentlicht in:Kidney & blood pressure research 2019-08, Vol.44 (4), p.835-847
Hauptverfasser: Barić, Lidija, Drenjančević, Ines, Matić, Anita, Stupin, Marko, Kolar, Luka, Mihaljević, Zrinka, Lenasi, Helena, Šerić, Vatroslav, Stupin, Ana
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine
Adolescent
Aldosterone
Angiotensin
Angiotensins
Blood flow
Blood pressure
Blood Pressure - drug effects
Body composition
Body Composition - drug effects
Body Fluids - drug effects
Cardiovascular disease
Creatinine
Cyanides
Diet
Dilation
Doppler effect
Edema
Endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Female
Glucocorticoids
Health aspects
Heart rate
High-salt diet
Humans
Hypertension
Iontophoresis
Laboratories
Male
Menstruation
Microcirculation
Microvasculature
Microvessels - cytology
Nitroprusside
Nutrient deficiency
Oxidative stress
Physiology
Potassium
Renin
Renin-angiotensin system
Research Article
Retention
Salt
Salt loading
Salts
Skin
Sodium
Sodium (Nutrient)
Sodium Chloride, Dietary - pharmacology
Sodium nitroprusside
Studies
Time Factors
Urea
Urine
Vascular endothelium
Vasodilation
Vasodilation - drug effects
Young Adult
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Zusammenfassung:Objectives: We aimed to assess whether a 7-day high-salt (HS) diet affects endothelium-dependent and/or endothelium-independent microvascular function in the absence of changes in arterial blood pressure (BP), and to determine whether such microvascular changes are associated with changes in body composition and fluid status in healthy young humans. Materials and Methods: Fifty-three young healthy individuals (28 women and 25 men) were assigned to a 7-day low-salt diet (
ISSN:1420-4096
1423-0143
DOI:10.1159/000501747