Efficacy and tolerability of perampanel as an adjunct therapy in refractory epilepsy from real-world experience

Efficacy and tolerability of perampanel as an adjunct therapy in refractory epilepsy from real-world experience

•PER performs consistently in real life when compared in clinical trials.•Dizziness and psychiatric adverse effects are common causes of intolerance.•Concomitant EIAEDs may affect the efficacy of PER.

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Veröffentlicht in:Journal of the neurological sciences 2019-10, Vol.405, p.116416-116416, Article 116416
Hauptverfasser: Chang, Richard Shek-kwan, Lui, Hoi Ki Kate, Leung, Yu Hin Ian, Leung, William C.Y., Yam, Ka Keung, Wang, Yujie
Format: Artikel
Sprache:eng
Schlagworte:
Anti-epileptic drug
Epilepsy
Perampanel
Seizure
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Beschreibung
Zusammenfassung:•PER performs consistently in real life when compared in clinical trials.•Dizziness and psychiatric adverse effects are common causes of intolerance.•Concomitant EIAEDs may affect the efficacy of PER.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2019.08.001