Pathogenicity of two Chinese Seneca Valley virus (SVV) strains in pigs

Seneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SVV strains (GD-S5/2018 and GD04/2017) in China, experimental infections of pigs were performed. In pig experiments, both SVV strains successfully infected all animals, evidenced by presence of virus shedding and robust protective antibody responses. SVV GD-S5/2018 infection resulted in characteristic clinical signs, and ulcerative lesions on the tongue and gums. However, SVV GD04/2017 did not cause any clinical symptoms except depression in pigs during the experiment. Taken together, these results demonstrate that SVV GD-S5/2018 is a virulent strain for pigs, whereas SVV GD04/2017 is nearly avirulent. The established animal models for SVV infection will be utilized to dissect the immunity and pathogenesis, and develop vaccines and antivirals. •Seneca Valley virus is the causative agent of SVV-associated vesicular disease (SAVD).•Pathogenicity of two Chinese SVV strains were determined in pigs.•SVV GD-S5/2018 infection resulted in ulcerative lesions on the tongue and gum in pigs.•Investigating infection dynamics and protective immune response against SVV infection.•The pig model were preliminarily established for SVV infection.