Damage Control in the Developing Brain: Tradeoffs and Consequences

Damage Control in the Developing Brain: Tradeoffs and Consequences

Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these questions and examines the consequences of both...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2019-10, Vol.42 (10), p.661-663
Hauptverfasser: Alsina, Fernando C., Silver, Debra L.
Format: Artikel
Sprache:eng
Schlagworte:
Aneuploidy
Brain
genome stability
Genomic Instability
Humans
microcephaly
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Zusammenfassung:Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these questions and examines the consequences of both inducing genomic instability and suppressing safeguard mechanisms for the development of the cerebral cortex.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2019.08.004