Extracellular vesicles in cancer nanomedicine

To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review...

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Veröffentlicht in:	Seminars in cancer biology 2021-02, Vol.69, p.212-225
Hauptverfasser:	Tarasov, Vadim V., Svistunov, Andrey A., Chubarev, Vladimir N., Dostdar, Samira A., Sokolov, Alexander V., Brzecka, Anna, Sukocheva, Olga, Neganova, Margarita E., Klochkov, Sergey G., Somasundaram, Siva G., Kirkland, Cecil E., Aliev, Gjumrakch
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Cancer Drug Delivery Systems Exosomes Extracellular vesicles Extracellular Vesicles - chemistry Humans Nanodrug delivery Nanomedicine Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - pathology Vaccines
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Beschreibung
Zusammenfassung:	To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.
ISSN:	1044-579X 1096-3650
DOI:	10.1016/j.semcancer.2019.08.017