Rapid and automated production of [68Ga]gallium chloride and [68Ga]Ga-DOTA-TATE on a medical cyclotron

The demand for Gallium-68 (68Ga) for labelling PET radiopharmaceuticals has increased over the past few years. 68Ga is obtained through the decayed parent radionuclide 68Ge using commercial 68Ge/68Ga generators. The principal limitation of commercial 68Ge/68Ga generators is that only a limited and f...

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Veröffentlicht in:	Nuclear medicine and biology 2019-07, Vol.74-75, p.12-18
Hauptverfasser:	Tieu, William, Hollis, Courtney A., Kuan, Kevin K.W., Takhar, Prab, Stuckings, Mick, Spooner, Nigel, Malinconico, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium chloride Automation Cyclotron Cyclotrons Cyclotrons - instrumentation DOTA-TATE Energy Ga-68 Gallium Gallium - chemistry Gallium chloride Gallium Radioisotopes - isolation & purification Gallium Radioisotopes - metabolism Generators Humans Impurities Irradiation Isotope Labeling - methods Labeling Octanol Organometallic Compounds - chemistry Organometallic Compounds - isolation & purification Organometallic Compounds - metabolism PET Platinum Purification Radiation Radioisotopes Radiolabelling Radionuclide Generators - instrumentation Radiopharmaceuticals - isolation & purification Radiopharmaceuticals - metabolism Resins Solid targetry Zinc Zinc chloride
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Beschreibung
Zusammenfassung:	The demand for Gallium-68 (68Ga) for labelling PET radiopharmaceuticals has increased over the past few years. 68Ga is obtained through the decayed parent radionuclide 68Ge using commercial 68Ge/68Ga generators. The principal limitation of commercial 68Ge/68Ga generators is that only a limited and finite quantity of 68Ga (
ISSN:	0969-8051 1872-9614
DOI:	10.1016/j.nucmedbio.2019.07.005