MicroRNA Alteration in Developing Rat Oligodendrocyte Precursor Cells Induced by Hypoxia-Ischemia

MicroRNA Alteration in Developing Rat Oligodendrocyte Precursor Cells Induced by Hypoxia-Ischemia

Abstract microRNAs (miRNAs) are involved in the pathogenesis of white matter injury (WMI). However, their roles in developing rat brains under hypoxia-ischemia (HI) insult remain unknown. Here, we examined the expression profiles of miRNAs in oligodendrocyte precursor cells using microarray analysis...

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Veröffentlicht in:Journal of neuropathology and experimental neurology 2019-10, Vol.78 (10), p.900-909
Hauptverfasser: Su, Xiaojuan, Xiao, Dongqiong, Huang, Lingyi, Li, Shiping, Ying, Junjie, Tong, Yu, Ye, Qianghua, Mu, Dezhi, Qu, Yi
Format: Artikel
Sprache:eng
Schlagworte:
Cerebral ischemia
Development and progression
Genetic aspects
Health aspects
Hypoxia
Ischemia
MicroRNA
MicroRNAs
Oligodendroglia
Pathogenesis
Structure
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Zusammenfassung:Abstract microRNAs (miRNAs) are involved in the pathogenesis of white matter injury (WMI). However, their roles in developing rat brains under hypoxia-ischemia (HI) insult remain unknown. Here, we examined the expression profiles of miRNAs in oligodendrocyte precursor cells using microarray analysis. We identified 162 miRNAs and only 6 were differentially regulated in HI compared with sham. Next, we used these 6 miRNAs and 525 extensively changed coding genes (fold change absolute: FC(abs) ≥2, p 
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nlz071