Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies
Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of...
Gespeichert in:
| Veröffentlicht in: | Heart failure reviews 2020-03, Vol.25 (2), p.277-294 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 294 |
|---|---|
| container_issue | 2 |
| container_start_page | 277 |
| container_title | Heart failure reviews |
| container_volume | 25 |
| creator | Katzmann, Julius L. Schlattmann, Peter Rigopoulos, Angelos G. Noutsias, Ewa Bigalke, Boris Pauschinger, Matthias Tschope, Carsten Sedding, Daniel Schulze, P. Christian Noutsias, Michel |
| description | Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of IHC proof of InfCM. The mean IHC detection rate of InfCM was 50.8% (95% CI 47.7–53.8%; range 18.4–91.7%). A publication bias was excluded (Funnel Plot
p
= 0.4264). This IHC detection rate was significantly (
p
|
| doi_str_mv | 10.1007/s10741-019-09835-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2270003077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2269794394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-3359256bba90972bb7c9378e45f5ee6e3ecefd142a9b14648fb5df513a19252d3</originalsourceid><addsrcrecordid>eNp9kUtLxDAUhYMoOo7-ARdScOMmmlebyVLEF4y40XVI29uZaNuMSbrovzfzUMGFEEjC-c69cA5CZ5RcUULkdaBECooJVZioGc-x2kMTmkuOJWdsP735jGFBhTxCxyG8E0KEEuQQHXHKVSELNkEfzxANNr1px2BD5vosLiGzXTf0bmlDdK1b2Mq0WQ0RqmgT4JrM9k1rus5E58esMr62rhvdysTlmLQM-nr93wjJWlq3ChbCCTpoTBvgdHdP0dv93evtI56_PDzd3sxxJQSNmPNcsbwoS6OIkqwsZaW4nIHImxygAA4VNDUVzKiSikLMmjKvm5xyQ5OP1XyKLrdzV959DhCi7myooG1ND24ImjGZouBEyoRe_EHf3eBTGmuqUFIJns4UsS1VeReCh0avvO2MHzUlel2F3lahUxV6U4VWyXS-Gz2UHdQ_lu_sE8C3QEhSvwD_u_ufsV-CQZYb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2269794394</pqid></control><display><type>article</type><title>Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies</title><source>MEDLINE</source><source>SpringerLink</source><creator>Katzmann, Julius L. ; Schlattmann, Peter ; Rigopoulos, Angelos G. ; Noutsias, Ewa ; Bigalke, Boris ; Pauschinger, Matthias ; Tschope, Carsten ; Sedding, Daniel ; Schulze, P. Christian ; Noutsias, Michel</creator><creatorcontrib>Katzmann, Julius L. ; Schlattmann, Peter ; Rigopoulos, Angelos G. ; Noutsias, Ewa ; Bigalke, Boris ; Pauschinger, Matthias ; Tschope, Carsten ; Sedding, Daniel ; Schulze, P. Christian ; Noutsias, Michel</creatorcontrib><description>Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of IHC proof of InfCM. The mean IHC detection rate of InfCM was 50.8% (95% CI 47.7–53.8%; range 18.4–91.7%). A publication bias was excluded (Funnel Plot
p
= 0.4264). This IHC detection rate was significantly (
p
< 0.0001) higher compared to the histological detection of myocarditis according to the Dallas criteria (mean 8.04%; 95% CI 5.08–12.5%; subset of 3274 patients in 30 publications). However, 13 different diagnostic IHC criteria were described in the publications, with various thresholds of diverse phenotypes of quantified infiltrates, and endothelial expression of diverse cell adhesion molecules (CAM), quantified either visually or by digital image analysis (DIA). The comparison of IHC with cardiac magnetic resonance (CMR) data available in a subset of 13 publications with 1185 patients revealed a sensitivity for CMR of 69% (95% CI 58–79%), a specificity of 73% (95% CI 59–84%), and a ROC-AUC of 0.77 (95% CI 0.73–0.81). This meta-analysis encompassing 10,491 patients confirms a mean detection rate of InfCM in 50.8% of EMB, being significantly more sensitive compared to the histological Dallas criteria. IHC cannot be fully substituted by CMR. However, standardization of the diverse IHC markers and protocols seems pertinent, especially considering the published adverse prognostic impact of IHC-confirmed InfCM and its published suitability for the selection of candidates responding favorably to immunosuppression.</description><identifier>ISSN: 1382-4147</identifier><identifier>EISSN: 1573-7322</identifier><identifier>DOI: 10.1007/s10741-019-09835-9</identifier><identifier>PMID: 31396762</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biopsy - methods ; Cardiology ; Cardiomyopathies - diagnosis ; Cardiomyopathy ; Cell adhesion & migration ; Cell adhesion molecules ; Heart diseases ; Humans ; Image processing ; Immunohistochemistry - methods ; Immunosuppression ; Inflammation ; Medicine ; Medicine & Public Health ; Meta-analysis ; Myocarditis ; Myocardium - pathology ; Phenotypes ; Standardization</subject><ispartof>Heart failure reviews, 2020-03, Vol.25 (2), p.277-294</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Heart Failure Reviews is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-3359256bba90972bb7c9378e45f5ee6e3ecefd142a9b14648fb5df513a19252d3</citedby><cites>FETCH-LOGICAL-c441t-3359256bba90972bb7c9378e45f5ee6e3ecefd142a9b14648fb5df513a19252d3</cites><orcidid>0000-0002-9066-5262</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10741-019-09835-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10741-019-09835-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31396762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katzmann, Julius L.</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Rigopoulos, Angelos G.</creatorcontrib><creatorcontrib>Noutsias, Ewa</creatorcontrib><creatorcontrib>Bigalke, Boris</creatorcontrib><creatorcontrib>Pauschinger, Matthias</creatorcontrib><creatorcontrib>Tschope, Carsten</creatorcontrib><creatorcontrib>Sedding, Daniel</creatorcontrib><creatorcontrib>Schulze, P. Christian</creatorcontrib><creatorcontrib>Noutsias, Michel</creatorcontrib><title>Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies</title><title>Heart failure reviews</title><addtitle>Heart Fail Rev</addtitle><addtitle>Heart Fail Rev</addtitle><description>Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of IHC proof of InfCM. The mean IHC detection rate of InfCM was 50.8% (95% CI 47.7–53.8%; range 18.4–91.7%). A publication bias was excluded (Funnel Plot
p
= 0.4264). This IHC detection rate was significantly (
p
< 0.0001) higher compared to the histological detection of myocarditis according to the Dallas criteria (mean 8.04%; 95% CI 5.08–12.5%; subset of 3274 patients in 30 publications). However, 13 different diagnostic IHC criteria were described in the publications, with various thresholds of diverse phenotypes of quantified infiltrates, and endothelial expression of diverse cell adhesion molecules (CAM), quantified either visually or by digital image analysis (DIA). The comparison of IHC with cardiac magnetic resonance (CMR) data available in a subset of 13 publications with 1185 patients revealed a sensitivity for CMR of 69% (95% CI 58–79%), a specificity of 73% (95% CI 59–84%), and a ROC-AUC of 0.77 (95% CI 0.73–0.81). This meta-analysis encompassing 10,491 patients confirms a mean detection rate of InfCM in 50.8% of EMB, being significantly more sensitive compared to the histological Dallas criteria. IHC cannot be fully substituted by CMR. However, standardization of the diverse IHC markers and protocols seems pertinent, especially considering the published adverse prognostic impact of IHC-confirmed InfCM and its published suitability for the selection of candidates responding favorably to immunosuppression.</description><subject>Biopsy - methods</subject><subject>Cardiology</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Cardiomyopathy</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Image processing</subject><subject>Immunohistochemistry - methods</subject><subject>Immunosuppression</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Myocarditis</subject><subject>Myocardium - pathology</subject><subject>Phenotypes</subject><subject>Standardization</subject><issn>1382-4147</issn><issn>1573-7322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtLxDAUhYMoOo7-ARdScOMmmlebyVLEF4y40XVI29uZaNuMSbrovzfzUMGFEEjC-c69cA5CZ5RcUULkdaBECooJVZioGc-x2kMTmkuOJWdsP735jGFBhTxCxyG8E0KEEuQQHXHKVSELNkEfzxANNr1px2BD5vosLiGzXTf0bmlDdK1b2Mq0WQ0RqmgT4JrM9k1rus5E58esMr62rhvdysTlmLQM-nr93wjJWlq3ChbCCTpoTBvgdHdP0dv93evtI56_PDzd3sxxJQSNmPNcsbwoS6OIkqwsZaW4nIHImxygAA4VNDUVzKiSikLMmjKvm5xyQ5OP1XyKLrdzV959DhCi7myooG1ND24ImjGZouBEyoRe_EHf3eBTGmuqUFIJns4UsS1VeReCh0avvO2MHzUlel2F3lahUxV6U4VWyXS-Gz2UHdQ_lu_sE8C3QEhSvwD_u_ufsV-CQZYb</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Katzmann, Julius L.</creator><creator>Schlattmann, Peter</creator><creator>Rigopoulos, Angelos G.</creator><creator>Noutsias, Ewa</creator><creator>Bigalke, Boris</creator><creator>Pauschinger, Matthias</creator><creator>Tschope, Carsten</creator><creator>Sedding, Daniel</creator><creator>Schulze, P. Christian</creator><creator>Noutsias, Michel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9066-5262</orcidid></search><sort><creationdate>20200301</creationdate><title>Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies</title><author>Katzmann, Julius L. ; Schlattmann, Peter ; Rigopoulos, Angelos G. ; Noutsias, Ewa ; Bigalke, Boris ; Pauschinger, Matthias ; Tschope, Carsten ; Sedding, Daniel ; Schulze, P. Christian ; Noutsias, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-3359256bba90972bb7c9378e45f5ee6e3ecefd142a9b14648fb5df513a19252d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biopsy - methods</topic><topic>Cardiology</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Cardiomyopathy</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Image processing</topic><topic>Immunohistochemistry - methods</topic><topic>Immunosuppression</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Myocarditis</topic><topic>Myocardium - pathology</topic><topic>Phenotypes</topic><topic>Standardization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katzmann, Julius L.</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Rigopoulos, Angelos G.</creatorcontrib><creatorcontrib>Noutsias, Ewa</creatorcontrib><creatorcontrib>Bigalke, Boris</creatorcontrib><creatorcontrib>Pauschinger, Matthias</creatorcontrib><creatorcontrib>Tschope, Carsten</creatorcontrib><creatorcontrib>Sedding, Daniel</creatorcontrib><creatorcontrib>Schulze, P. Christian</creatorcontrib><creatorcontrib>Noutsias, Michel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart failure reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katzmann, Julius L.</au><au>Schlattmann, Peter</au><au>Rigopoulos, Angelos G.</au><au>Noutsias, Ewa</au><au>Bigalke, Boris</au><au>Pauschinger, Matthias</au><au>Tschope, Carsten</au><au>Sedding, Daniel</au><au>Schulze, P. Christian</au><au>Noutsias, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies</atitle><jtitle>Heart failure reviews</jtitle><stitle>Heart Fail Rev</stitle><addtitle>Heart Fail Rev</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>25</volume><issue>2</issue><spage>277</spage><epage>294</epage><pages>277-294</pages><issn>1382-4147</issn><eissn>1573-7322</eissn><abstract>Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of IHC proof of InfCM. The mean IHC detection rate of InfCM was 50.8% (95% CI 47.7–53.8%; range 18.4–91.7%). A publication bias was excluded (Funnel Plot
p
= 0.4264). This IHC detection rate was significantly (
p
< 0.0001) higher compared to the histological detection of myocarditis according to the Dallas criteria (mean 8.04%; 95% CI 5.08–12.5%; subset of 3274 patients in 30 publications). However, 13 different diagnostic IHC criteria were described in the publications, with various thresholds of diverse phenotypes of quantified infiltrates, and endothelial expression of diverse cell adhesion molecules (CAM), quantified either visually or by digital image analysis (DIA). The comparison of IHC with cardiac magnetic resonance (CMR) data available in a subset of 13 publications with 1185 patients revealed a sensitivity for CMR of 69% (95% CI 58–79%), a specificity of 73% (95% CI 59–84%), and a ROC-AUC of 0.77 (95% CI 0.73–0.81). This meta-analysis encompassing 10,491 patients confirms a mean detection rate of InfCM in 50.8% of EMB, being significantly more sensitive compared to the histological Dallas criteria. IHC cannot be fully substituted by CMR. However, standardization of the diverse IHC markers and protocols seems pertinent, especially considering the published adverse prognostic impact of IHC-confirmed InfCM and its published suitability for the selection of candidates responding favorably to immunosuppression.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31396762</pmid><doi>10.1007/s10741-019-09835-9</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-9066-5262</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1382-4147 |
| ispartof | Heart failure reviews, 2020-03, Vol.25 (2), p.277-294 |
| issn | 1382-4147 1573-7322 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2270003077 |
| source | MEDLINE; SpringerLink |
| subjects | Biopsy - methods Cardiology Cardiomyopathies - diagnosis Cardiomyopathy Cell adhesion & migration Cell adhesion molecules Heart diseases Humans Image processing Immunohistochemistry - methods Immunosuppression Inflammation Medicine Medicine & Public Health Meta-analysis Myocarditis Myocardium - pathology Phenotypes Standardization |
| title | Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T17%3A48%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analysis%20on%20the%20immunohistological%20detection%20of%20inflammatory%20cardiomyopathy%20in%20endomyocardial%20biopsies&rft.jtitle=Heart%20failure%20reviews&rft.au=Katzmann,%20Julius%20L.&rft.date=2020-03-01&rft.volume=25&rft.issue=2&rft.spage=277&rft.epage=294&rft.pages=277-294&rft.issn=1382-4147&rft.eissn=1573-7322&rft_id=info:doi/10.1007/s10741-019-09835-9&rft_dat=%3Cproquest_cross%3E2269794394%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2269794394&rft_id=info:pmid/31396762&rfr_iscdi=true |