Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies

Meta-analysis on the immunohistological detection of inflammatory cardiomyopathy in endomyocardial biopsies

Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of...

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Veröffentlicht in:Heart failure reviews 2020-03, Vol.25 (2), p.277-294
Hauptverfasser: Katzmann, Julius L., Schlattmann, Peter, Rigopoulos, Angelos G., Noutsias, Ewa, Bigalke, Boris, Pauschinger, Matthias, Tschope, Carsten, Sedding, Daniel, Schulze, P. Christian, Noutsias, Michel
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy - methods
Cardiology
Cardiomyopathies - diagnosis
Cardiomyopathy
Cell adhesion & migration
Cell adhesion molecules
Heart diseases
Humans
Image processing
Immunohistochemistry - methods
Immunosuppression
Inflammation
Medicine
Medicine & Public Health
Meta-analysis
Myocarditis
Myocardium - pathology
Phenotypes
Standardization
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Zusammenfassung:Meta-analysis on immunohistological (IHC) concepts for the detection of inflammatory cardiomyopathy (InfCM) in endomyocardial biopsies (EMB). We included 61 publications, with 10,491 patients (mean age 47.1 years; men 66%) who underwent EMB and IHC evaluation. The 460 control patients were devoid of IHC proof of InfCM. The mean IHC detection rate of InfCM was 50.8% (95% CI 47.7–53.8%; range 18.4–91.7%). A publication bias was excluded (Funnel Plot p  = 0.4264). This IHC detection rate was significantly ( p  
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-019-09835-9