CD4 recovery is associated with genetic variation in IFNγ and IL19 genes

Not all HIV-infected patients receiving cART are able to recover optimal CD4-T cell levels despite achieving undetectable viremia. We evaluated the potential association between polymorphisms (SNPs) in cytokines involved in immune response (IL15, IFNγ and IL19) and the failure to achieve optimal CD4...

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Veröffentlicht in:	Antiviral research 2019-10, Vol.170, p.104577-104577, Article 104577
Hauptverfasser:	García, Marcial, Jiménez-Sousa, María A., Blanco, Julià, Restrepo, Clara, Pacheco, Yolanda M., Brochado-Kith, Óscar, López-Bernaldo, Juan Carlos, Gutiérrez, Félix, Portilla, Joaquín, Estrada, Vicente, Górgolas, Miguel, Cabello, Alfonso, Resino, Salvador, Benito, José M, Rallón, Norma
Format:	Artikel
Sprache:	eng
Schlagworte:	IFNγ IL15 IL19 Immunological non-responder patients Low baseline CD4 counts
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Zusammenfassung:	Not all HIV-infected patients receiving cART are able to recover optimal CD4-T cell levels despite achieving undetectable viremia. We evaluated the potential association between polymorphisms (SNPs) in cytokines involved in immune response (IL15, IFNγ and IL19) and the failure to achieve optimal CD4 T-cells restoration after cART. For this, we carried out a retrospective study in 412 HIV-infected patients starting cART with CD4
ISSN:	0166-3542 1872-9096
DOI:	10.1016/j.antiviral.2019.104577