Multiple endocrine neoplasia: an update

Multiple endocrine neoplasia: an update

The multiple endocrine neoplasia (MEN) syndromes include MEN1, MEN2 (formerly MEN2A), MEN3 (formerly MEN2B) and the recently identified MEN4. Clinical presentations are varied and often relate to the overproduction of specific hormones. Understanding the genetics of each syndrome assists in determin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Internal medicine journal 2019-08, Vol.49 (8), p.954-961
Hauptverfasser: McDonnell, Jane E., Gild, Matti L., Clifton‐Bligh, Roderick J., Robinson, Bruce G.
Format: Artikel
Sprache:eng
Schlagworte:
Combined Modality Therapy
Endocrine Surgical Procedures
Genetic counseling
Genetic Markers
Genetic Testing
genetics
Humans
Malignancy
Morbidity
Multiple endocrine neoplasia
Multiple Endocrine Neoplasia - classification
Multiple Endocrine Neoplasia - diagnosis
Multiple Endocrine Neoplasia - genetics
Multiple Endocrine Neoplasia - therapy
Recurrence
screening
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The multiple endocrine neoplasia (MEN) syndromes include MEN1, MEN2 (formerly MEN2A), MEN3 (formerly MEN2B) and the recently identified MEN4. Clinical presentations are varied and often relate to the overproduction of specific hormones. Understanding the genetics of each syndrome assists in determining screening timelines. Treatments for each manifestation are dependent on location, risk of recurrence or malignancy, hormone excess and surgical morbidity. Multidisciplinary management should include geneticists, genetic counsellors, endocrinologists and endocrine surgeons.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.14394