Cyclosporine in treatment of progressive vitiligo: An open-label, single-arm interventional study

Cyclosporine interferes with the phosphorylation of nuclear factor of activated T cells (NFAT), a transcription factor, which is necessary for transcription of genes encoding interleukin-2 (IL-2). Sites that responded the most, in terms of repigmentation, were the neck and upper chest [Figure 1]a and [Figure 1]b. In addition to these regions, the sun-protected sites such as supra and infra clavicular areas, also showed meaningful repigmentation [Figure 2]a and [Figure 2]b. Cyclosporine was, by and large, well tolerated with only minor adverse effects observed in only a few patients [Table 1]. The limitations of this study include small sample size, female predominant sample, and the open-label study design.