A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma

Objective Clinical outcomes of patients with resected oral cavity squamous cell carcinoma (OCSCC) chiefly depend on the presence of specific clinicopathological risk factors (RFs). Here, we performed a combined analysis of FDG-PET, genetic markers, and clinicopathological RFs in an effort to improve...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of nuclear medicine and molecular imaging 2020, Vol.47 (1), p.84-93
Hauptverfasser: Liao, Chun-Ta, Hsieh, Chia-Hsun, Fan, Wen-Lang, Ng, Shu-Hang, Cheng, Nai-Ming, Lee, Li-Yu, Hsueh, Chuen, Lin, Chien-Yu, Fan, Kang-Hsing, Wang, Hung-Ming, Lin, Chih-Hung, Tsao, Chung-Kan, Kang, Chung-Jan, Fang, Tuan-Jen, Huang, Shiang-Fu, Chang, Kai-Ping, Lee, Li-Ang, Fang, Ku-Hao, Wang, Yu-Chien, Yang, Lan-Yan, Yen, Tzu-Chen
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objective Clinical outcomes of patients with resected oral cavity squamous cell carcinoma (OCSCC) chiefly depend on the presence of specific clinicopathological risk factors (RFs). Here, we performed a combined analysis of FDG-PET, genetic markers, and clinicopathological RFs in an effort to improve prognostic stratification. Methods We retrospectively reviewed the clinical records of 2036 consecutive patients with first primary OCSCC who underwent surgery between 1996 and 2016. Of them, 345 underwent ultra-deep targeted sequencing (UDTS, between 1996 and 2011) and 168 whole exome sequencing (WES, between 2007 and 2016). Preoperative FDG-PET imaging was performed in 1135 patients from 2001 to 2016. Complete data on FDG-PET, genetic markers, and clinicopathological RFs were available for 327 patients. Results Using log-ranked tests based on 5-year disease-free survival (DFS), the optimal cutoff points for maximum standardized uptake values (SUV-max) of the primary tumor and neck metastatic nodes were 22.8 and 9.7, respectively. The 5-year DFS rates were as follows: SUVtumor-max ≥ 22.8 or SUVnodal-max ≥ 9.7 ( n  = 77) versus SUVtumor-max 
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-019-04453-x