Outcomes of Non-B Non-C Hepatocellular Carcinoma with Reference to Patients with Interferon-Induced Hepatitis C Virus Eradication

Purpose This study aimed to evaluate survival outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) with reference to patients with HCC achieving sustained virological response (SVR) by preoperative interferon (IFN) treatment for chronic hepatitis C. Methods We examined 781 patie...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of gastrointestinal surgery 2020-08, Vol.24 (8), p.1809-1817
Hauptverfasser:	Shinkawa, Hiroji, Tanaka, Shogo, Takemura, Shigekazu, Ito, Tokuji, Aota, Takanori, Miyazaki, Toru, Kubo, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - surgery Gastroenterology Gastroenterology & Hepatology Hepacivirus Hepatitis Hepatitis C Humans Interferon Interferons - therapeutic use Life Sciences & Biomedicine Liver cancer Liver Neoplasms - surgery Medicine Medicine & Public Health Neoplasm Recurrence, Local - epidemiology Original Article Prognosis Retrospective Studies Science & Technology Surgery
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Purpose This study aimed to evaluate survival outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) with reference to patients with HCC achieving sustained virological response (SVR) by preoperative interferon (IFN) treatment for chronic hepatitis C. Methods We examined 781 patients who underwent hepatic resection for HCC. They were classified into NBNC-HCC, SVR-HCC, and non-SVR HCC groups. Results Multivariate analysis for recurrence-free survival (RFS) and overall survival (OS) revealed that the adjusted hazard ratios (HR) of NBNC-HCC and non-SVR HCC groups with reference to the SVR-HCC group were 1.46 ( p = 0.10) and 2.10 ( p
ISSN:	1091-255X 1873-4626
DOI:	10.1007/s11605-019-04339-1