Physiological differences in sarcolemmal excitability between human muscles
Introduction The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with...
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| Veröffentlicht in: | Muscle & nerve 2019-10, Vol.60 (4), p.433-436 |
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| creator | Lee, James H. F. Boland‐Freitas, Robert Ng, Karl |
| description | Introduction
The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles.
Methods
Muscle velocity recovery cycles were recorded from a proximal antigravity muscle, the rectus femoris, and compared with paired recordings from a distal non‐antigravity muscle, the tibialis anterior, in 34 normal individuals.
Results
Significant differences in muscle relative refractory period (3.55 millseconds vs 3.87 milliseconds, P = .002), early supernormality (14.22% vs 10.50%, P |
| doi_str_mv | 10.1002/mus.26645 |
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The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles.
Methods
Muscle velocity recovery cycles were recorded from a proximal antigravity muscle, the rectus femoris, and compared with paired recordings from a distal non‐antigravity muscle, the tibialis anterior, in 34 normal individuals.
Results
Significant differences in muscle relative refractory period (3.55 millseconds vs 3.87 milliseconds, P = .002), early supernormality (14.22% vs 10.50%, P < .0001), and late supernormality (5.43% vs 3.50%, P < .0001) were observed.
Discussion
The results strongly suggest a less negative RMP in tibialis anterior vs rectus femoris and attest to intermuscle differences in normal excitability and physiology. This novel finding employing an in vivo methodology highlights the need for muscle‐specific normative data in future studies.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26645</identifier><identifier>PMID: 31330047</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigravity ; Excitability ; Female ; Humans ; In vivo methods and tests ; Male ; Membrane potential ; Membrane Potentials - physiology ; Middle Aged ; Muscle contraction ; muscle fiber type ; muscle velocity recovery cycles ; Muscle, Skeletal - physiology ; Muscles ; Physiology ; Quadriceps Muscle - physiology ; Recovery (Medical) ; Reference Values ; Refractory period ; Refractory Period, Electrophysiological - physiology ; resting membrane potential ; Sarcolemma ; Sarcolemma - physiology ; Skeletal muscle ; Young Adult</subject><ispartof>Muscle & nerve, 2019-10, Vol.60 (4), p.433-436</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-65242fd55315b3cba8f79c5cac4270a596f53ef9021a37b597e1f51792a7eb433</citedby><cites>FETCH-LOGICAL-c3535-65242fd55315b3cba8f79c5cac4270a596f53ef9021a37b597e1f51792a7eb433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26645$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26645$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31330047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, James H. F.</creatorcontrib><creatorcontrib>Boland‐Freitas, Robert</creatorcontrib><creatorcontrib>Ng, Karl</creatorcontrib><title>Physiological differences in sarcolemmal excitability between human muscles</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles.
Methods
Muscle velocity recovery cycles were recorded from a proximal antigravity muscle, the rectus femoris, and compared with paired recordings from a distal non‐antigravity muscle, the tibialis anterior, in 34 normal individuals.
Results
Significant differences in muscle relative refractory period (3.55 millseconds vs 3.87 milliseconds, P = .002), early supernormality (14.22% vs 10.50%, P < .0001), and late supernormality (5.43% vs 3.50%, P < .0001) were observed.
Discussion
The results strongly suggest a less negative RMP in tibialis anterior vs rectus femoris and attest to intermuscle differences in normal excitability and physiology. This novel finding employing an in vivo methodology highlights the need for muscle‐specific normative data in future studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigravity</subject><subject>Excitability</subject><subject>Female</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Male</subject><subject>Membrane potential</subject><subject>Membrane Potentials - physiology</subject><subject>Middle Aged</subject><subject>Muscle contraction</subject><subject>muscle fiber type</subject><subject>muscle velocity recovery cycles</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscles</subject><subject>Physiology</subject><subject>Quadriceps Muscle - physiology</subject><subject>Recovery (Medical)</subject><subject>Reference Values</subject><subject>Refractory period</subject><subject>Refractory Period, Electrophysiological - physiology</subject><subject>resting membrane potential</subject><subject>Sarcolemma</subject><subject>Sarcolemma - physiology</subject><subject>Skeletal muscle</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAcx_EgipvTg29ACl700C0PTdIcZfiEioIOvJU0-8dlpO1sVubevRmbHgRPOeTDN-GH0CnBQ4IxHVVdGFIhMr6H-gQrmWZc5fuoj0mWp4Kp9x46CmGOMSa5kIeoxwhjGGeyjx5eZuvgGt98OKN9MnXWQgu1gZC4Ogm6NY2HqopX8GXcUpfOu-U6KWG5AqiTWVfpOonvGw_hGB1Y7QOc7M4Bmtxcv43v0sfn2_vx1WNqGGc8FZxm1E45Z4SXzJQ6t1IZbrTJqMSaK2E5A6swJZrJkisJxHIiFdUSyoyxAbrYdhdt89lBWBaVCwa81zU0XSgoFXlsS0EjPf9D503X1vF3USmi8jwjIqrLrTJtE0ILtli0rtLtuiC42CxcVJvsZuFoz3bFrqxg-it_Jo1gtAUr52H9f6l4mrxuk9_yiYTl</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Lee, James H. F.</creator><creator>Boland‐Freitas, Robert</creator><creator>Ng, Karl</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Physiological differences in sarcolemmal excitability between human muscles</title><author>Lee, James H. F. ; Boland‐Freitas, Robert ; Ng, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-65242fd55315b3cba8f79c5cac4270a596f53ef9021a37b597e1f51792a7eb433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigravity</topic><topic>Excitability</topic><topic>Female</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Male</topic><topic>Membrane potential</topic><topic>Membrane Potentials - physiology</topic><topic>Middle Aged</topic><topic>Muscle contraction</topic><topic>muscle fiber type</topic><topic>muscle velocity recovery cycles</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscles</topic><topic>Physiology</topic><topic>Quadriceps Muscle - physiology</topic><topic>Recovery (Medical)</topic><topic>Reference Values</topic><topic>Refractory period</topic><topic>Refractory Period, Electrophysiological - physiology</topic><topic>resting membrane potential</topic><topic>Sarcolemma</topic><topic>Sarcolemma - physiology</topic><topic>Skeletal muscle</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, James H. F.</creatorcontrib><creatorcontrib>Boland‐Freitas, Robert</creatorcontrib><creatorcontrib>Ng, Karl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, James H. F.</au><au>Boland‐Freitas, Robert</au><au>Ng, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological differences in sarcolemmal excitability between human muscles</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2019-10</date><risdate>2019</risdate><volume>60</volume><issue>4</issue><spage>433</spage><epage>436</epage><pages>433-436</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles.
Methods
Muscle velocity recovery cycles were recorded from a proximal antigravity muscle, the rectus femoris, and compared with paired recordings from a distal non‐antigravity muscle, the tibialis anterior, in 34 normal individuals.
Results
Significant differences in muscle relative refractory period (3.55 millseconds vs 3.87 milliseconds, P = .002), early supernormality (14.22% vs 10.50%, P < .0001), and late supernormality (5.43% vs 3.50%, P < .0001) were observed.
Discussion
The results strongly suggest a less negative RMP in tibialis anterior vs rectus femoris and attest to intermuscle differences in normal excitability and physiology. This novel finding employing an in vivo methodology highlights the need for muscle‐specific normative data in future studies.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31330047</pmid><doi>10.1002/mus.26645</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigravity Excitability Female Humans In vivo methods and tests Male Membrane potential Membrane Potentials - physiology Middle Aged Muscle contraction muscle fiber type muscle velocity recovery cycles Muscle, Skeletal - physiology Muscles Physiology Quadriceps Muscle - physiology Recovery (Medical) Reference Values Refractory period Refractory Period, Electrophysiological - physiology resting membrane potential Sarcolemma Sarcolemma - physiology Skeletal muscle Young Adult |
| title | Physiological differences in sarcolemmal excitability between human muscles |
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