Lemon juice catalyzed C–C bond formation via C–H activation of methylarene: a sustainable synthesis of chromenopyrimidines

An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP as an oxidant. This...

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Veröffentlicht in:	Molecular diversity 2020-08, Vol.24 (3), p.717-725
Hauptverfasser:	Kumari, Savita, Singh, Sundaram, Srivastava, Vandana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biochemistry Biodegradation Biomedical and Life Sciences Carbon - chemistry Catalysis Catalysts Chemistry Techniques, Synthetic Citrus - chemistry Fruit and Vegetable Juices Green Chemistry Technology Hydrocarbons Hydrocarbons, Aromatic - chemistry Kinetics Life Sciences Organic Chemistry Original Article Oxidation Pharmacy Polymer Sciences Pyrimidines - chemical synthesis Pyrimidines - chemistry Solvents Temperature
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Beschreibung
Zusammenfassung:	An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP as an oxidant. This transformation involves metal-free C–C bond formation via C–H activation of methylarenes under mild reaction conditions. Graphical abstract
ISSN:	1381-1991 1573-501X
DOI:	10.1007/s11030-019-09980-1