CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma

Oral Squamous Cell Carcinoma (OSCC) is one of the major causes of cancer related deaths worldwide. Presence of chemoresistant cancer stem cells is the major reason behind metastasis, tumor relapse and treatment resistance in OSCC. STAT 3 signalling plays a key role in survival of cancer stem cells (...

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Veröffentlicht in:Medical hypotheses 2019-08, Vol.129, p.109241-109241, Article 109241
Hauptverfasser: Pindiprolu, Sai Harshini, Pindiprolu, Sai Kiran S.S.
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Sprache:eng
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Zusammenfassung:Oral Squamous Cell Carcinoma (OSCC) is one of the major causes of cancer related deaths worldwide. Presence of chemoresistant cancer stem cells is the major reason behind metastasis, tumor relapse and treatment resistance in OSCC. STAT 3 signalling plays a key role in survival of cancer stem cells (CSC’s), Epithelial Mesenchymal Transition (EMT) mediated metastasis in OSCC. CD 133 is the surface marker for identification of cancer stem cells. In the present study we hypothesise the selective targeting of CSC’s using CD 133 mediated delivery of STAT 3 inhibitor, Niclosamide to specifically target CSC’s and Non CSC’s.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.109241